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TERAPIA MOLECOLARE
IN ONCOLOGIA

Author edited by Dino Amadori and Carlo Maria Croce
Volume 4-colors + black and white, hardcover, 21×27 cm
Pages XX-420 with 54 images
audience oncologists
publication
date
October 2005

120,00 € 50,00 €

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SKU: 978-88-8678693-5 Categories: Human Medicine, Oncology Tags: Carlo Maria Croce, Dino Amadori, offer, oncology
SKU: 978-88-8678693-5Categories: Human Medicine, OncologyTags: Carlo Maria Croce, Dino Amadori, offer, oncology

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Il termine terapia molecolare mirata è usato per riferirsi ad agenti che colpiscono i percorsi specifici attivati nei processi di crescita, sopravvivenza, invasione e metastasi delle cellule neoplastiche e nella neangiogenesi tumorale.
Il grande e forse eccessivo ottimismo, provocato dal progressivo approfondimento delle conoscenze di questi meccanismi, ha ricevuto un impulso ulteriore con l’ingresso sulla scena terapeutica dell’imatinib e di altri farmaci appartenenti alla categoria degli agenti mirati al bersaglio biomolecolare, fra i quali alcuni anticorpi monoclonali (trastuzumab, rituximab, cetuximab, bevacizumab) e alcune piccole molecole, già entrati nella pratica clinica.
Ma la domanda che ci si deve porre è se tale entusiasmo sia giustificato e suffragato da dati scientificamente forti e clinicamente provati.
Le difficoltà incontrate nella ricerca e nello sviluppo di nuove molecole veramente efficaci e i deludenti risultati ottenuti nelle prime fasi della vita di alcuni di questi agenti e, non ultimi, gli alti costi delle terapie debbono indurre a una maggiore cautela. L’oncologo medico ha il dovere irrinunciabile di possedere sufficiente cultura per essere in grado di utilizzare appropriatamente queste nuove terapie nei suoi processi decisionali diagnostico-terapeutici.
La trattazione è suddivisa in tre parti, che riguardano rispettivamente la biologia molecolare della proliferazione cellulare, la farmacologia e lo sviluppo clinico degli agenti mirati al bersaglio biomolecolare, la caratterizzazione biomolecolare e le terapie delle diverse neoplasie maligne.

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SVILUPPO DEI FARMACI ONCOLOGICI CON BERSAGLIO MOLECOLARE dalla tradizione a...CELLULE STAMINALI: DALLA BIOLOGIA ALLE TERAPIE CELLULARI
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